Patients must be at least 18 years old and meet one of the following clinical requirements when GLP-1 therapy begins: A body mass index, or BMI, of 35 or higher A BMI between 30 and 34.99 with at least one qualifying health condition A BMI between 27 and 29.99 with at least one qualifying higher-risk health condition For someone with a BMI between 30 and 34.99, qualifying conditions may include heart failure with preserved ejection fraction, uncontrolled high blood pressure, stage 3a or higher chronic kidney disease, prediabetes, a previous heart attack or stroke, or symptomatic peripheral artery disease
Obesity in Adults: Drug Therapy. Edited by F Xavier Pi-Sunyer and Sara Swenson, UpToDate, Wolters Kluwer, 21 Dec
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Muscle cramps could be due to dehydration, changes in electrolyte levels, or metabolic shifts caused by the medication
The improvement during this phase often feels dramatic because it contrasts sharply with the initial flare-up period
