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10.1016/j.tins.2006.03.006 Trends Neurosci

Diabetologia special issue

Key findings include: Upregulation of Shh pathway components in ischemic brain regions Enhanced neural stem cell proliferation and differentiation Improved angiogenesis supporting tissue repair Modulation of blood-brain barrier integrity The Shh pathway activation appears particularly relevant in stroke recovery models, where enhanced neurogenesis and vascular support correlate with functional improvements

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The American Thyroid Association recommends checking thyroid-stimulating hormone (TSH) levels 4-6 weeks after initiating levothyroxine or changing doses, then every 6-12 months once stable

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