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doi: 10.3389/fphys.2025.1651151 Received 20 June 2025 Revised 17 October 2025 Accepted 23 October 2025 Published 16 December 2025 Volume 16 - 2025 Edited by Geoffrey A

Inhibiting DPP-IV activity helps stabilize the bodys natural GLP-1 levels, promoting insulin secretion, a recognized mechanism for supporting healthy blood sugar regulation

Nevertheless, these data establish that biased agonism at the GLP-1R is a key determinant of functional outcomes

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In a study by Rotondo Dottore, G., it was mentioned that H2O2 has a dual effect on fibroblast cell proliferation, with low concentrations of H2O2 inducing proliferation and releasing cytokines, while high concentrations of H2O2 are cytotoxic, when cell viability decreases (9, 31)

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