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Two weeks of exenatide treatment twice daily, 1 h before morning and evening meals, significantly reduces plasma TG following these meals (50% carbohydrate, 20% protein, and 30% fat) compared to placebo but TG levels rise to similar levels as placebo following the midday meal, where no changes in post-prandial FFA concentrations are observed (Schwartz et al., 2008)

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158,164 In parallel, lipid-induced IR in skeletal muscle leads to defected insulin signaling and decreased insulin-stimulated glucose transport mediated by GLUT4 translocation, and not by glycolysis inhibition as Randle hypothesized