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IGF-1 LR3's structural changes significantly reduce its binding affinity for IGFBPs by approximately 100-fold, allowing greater interaction with IGF-1 receptors on target cells

Individuals with insulin resistance, elevated inflammation, or dysregulated adipose tissue may have blunted beta-3 receptor signaling that limits the peptides effectiveness

Most available studies are small, uncontrolled, or industry-sponsored

doi: 10.1371/journal.pone.0021772 33 TakPPBalanescuATseluykoVBojinSDrescherEDairaghiDet al

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