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eNOS uncoupling Under certain conditions, eNOS can become uncoupled, shifting from producing NO to generating superoxide (O 2 ), which not only reduces NO availability but also increases oxidative stress, reducing endothelial dysfunction

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This drew our attention to the ubiquitin-related protein UBE2m, which is a ubiquitin-conjugating enzyme essential for the neddylation that was significantly enriched (Fig