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There are several underlying reasons for the methyl trap: the concentration of Hcy drops, oxidative stress inhibits MS, and the drop in [SAM] releases the inhibition of MTHFR, which drives more folate towards the 5mTHF form
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10.1074/jbc.M305108200 92 NishidaM.HaradaS.NoguchiS.SatowY.InoueH.TakahashiK