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Theres some scientific rationale supporting this possibility, as it has been hypothesized that GLP1 agonists may decrease rewarding/reinforcing effects of alcohol and other drugs of abuse

The molecule with the best activity, 84 , proved to be a mixedtype XO inhibitor, and from in vitro tests, exhibited IC 50 values of 0.022 M, equivalent to topiroxostat, the drug used as a positive control (Figure 26)

Screening and data extraction were not performed in duplicate, further increasing risk of selection bias

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