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Patients who are overweight (body mass index greater than 27)

Laboratory and review evidence consolidated in two 2025 papers (Paschou IA et al, Endocrine 89(3):680-685, PMID 40498168

Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response

Participants were recruited from 23 clinical study centers in the United States between 31 July 1996 and 18 May 1999, and randomized to either LI or metformin or placebo groups

A double reciprocal replot of k obs versus [I] did not fit to a linear relationship (unpublished data)