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The importance of reducing Cys274/Cys276 in DnaJb5 for interaction with HDAC4 has been emphasized, as has the impact of decreasing Cys667/Cys669 in HDAC4 on preventing its nuclear export

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However, only a minority of these reactions depend on immunological mechanisms (i.e., allergy) (Bjrksten & Kjellman, 1987)

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An Integrative Approach to Treatment The current evolution in integrative treatment still includes pharmaceuticals, but for shorter courses than the former years-long treatments