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Mol Neurodegener 15(1):30 Wang Z-J, Li X-R, Chai S-F, Li W-R, Li S, Hou M et al (2023) Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimers disease via the GLP-1R/SIRT1/GLUT4 pathway

Outside that window, the brand states replacements generally can't be approved - though they note occasional exceptions for situations like hospitalization

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Wegovy HD 7.2 mg, the recently approved higher-dose version of semaglutide, shows a similar dose-dependent increase, with dysesthesia reported in roughly 22% of people at that dose compared to about 6% at the standard 2.4 mg dose

A 68-week clinical trial found Wegovy to be more effective for weight loss than Saxenda in adults with overweight or obesity