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They improve insulin sensitivity in peripheral tissues

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Podiatrists have noted this can include a loss of soft tissue, noting a reduction in fat padding can affect the cushioning of the heels and balls of the feet, resulting in foot pain

GLP-1 receptor agonists mimic the action of this naturally occurring hormone

In adipose tissue, GLP-1 receptors are directly expressed and activation impacts apoptosis and preadipocyte proliferation, as well as fat deposition through regulation of lipolysis, fatty acid oxidation, and adipocyte differentiation

Early Evidence In the latest GLP-1 study 2025 , orforglipron showed early promise for adults with obesity and those living with type 2 diabetes, especially at the highest evaluated dose