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In naturally aged mice and in doxorubicin-treated mice, FOXO4-DRI treatment significantly improved physical fitness, restored fur density, improved renal function, and improved liver function effects attributed to the selective elimination of accumulated senescent cells
DOI: 10.1152/japplphysiol.00945.2010
Baldassarri, C
In clinical trials, however, preclinical cardiovascular benefits were not sustained, and increased hospitalizations for HF and fractures were observed
Within 120 days of discontinuation, participants regained an average of 25% of their lost weight
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