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Homozygous NKO mice exhibit embryonic lethality [68], whereas heterozygous NKO mice exhibit IGT due to impaired insulin secretion [68] and heart failure due to progressive mitochondrial dysfunction induced by pressure overload [69]

reported post-VSG increases in lumbar BMAT alongside peripheral MAT reductions, underscoring region-specific fatbone interactions, although other studies report a reduction in BMAT with VSG

doi: 10.1038/s41467-021-23014-1 264 FriedLPTangenCMWalstonJNewmanABHirschCGottdienerJet al

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Instead of several months, treatment may extend to a year or more