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Besides depleting CoA, low Cys availability can compromise Fe-S cluster assembly, downregulate mitochondrial protein biosynthesis or disturb the redox balance through low GSH
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Its major role is to eliminate H 2 O 2 , hydroperoxides, and lipid hydroperoxides by catalyzing the conversion of glutathione to oxidized glutathione ( GPX3 gene contains glucocorticoid-binding elements (GRE)
Wessells et al., Intl
Patient-derived tumour organoids: a bridge between cancer biology and personalised therapy
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