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[Abstract] Mol Biomed

Age-standardized prevalence and disability-adjusted life years (DALYs) associated with PD have shown a 156% increase between 1990 and 2019 (Zhong and Zhu, 2022)

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206,220,221 Given that endoplasmic reticulum stress, impaired autophagy and proliferation, and increased apoptosis are all suggested to promote islet beta-cell pathology in T2D, and the findings that GLP-1R activation can influence all of these give GLP-1 and its analogues a role beyond just enhancing insulin secretion