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One concern about the medicationsis that some studies suggest they may increase the risk of thyroid cancer.However, these studies point out that the health benefits of the drugs are likely to outweigh this increased risk

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To put that into perspective, if starting BMI was 32, a 16% reduction would bring it down to 27

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Metformin acts on intestinal AMPK, inhibiting the farnesoid X receptor (FXR), the nuclear receptor for maintaining bile acid homeostasis, consequently increasing the bile acid pool and stimulating GLP-1 secretion [110,111,112]