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injections with 100 nmol kg 1 GLP-1MK-801 or vehicle, or calorie restriction to match the weight loss trajectory of the GLP-1MK-801 group for 10 days

GLP-1 therapy can play a role in making this outcome more achievable for many patients

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However, this data comes from observational studies, not randomized controlled trials, so it should be interpreted cautiously

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Safety: This reclassification acknowledges the safety data presented in recent years and ensures that patients can access these tools through regulated, high-quality pharmaceutical channels rather than unregulated sources