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Application of an Integrative Drug Safety Model for Detection of Adverse Drug Events Associated With Inhibition of Glutathione Peroxidase 1 in Chronic Obstructive Pulmonary Disease

Martin G, Andriamanalijaona R, Mathy-Hartert M, Henrotin Y, Pujol J-P

6-month RCT (n = 54) documented dose- and time-dependent increases in body glutathione stores, with the 1,000 mg/day group achieving 30-35% increases in erythrocyte, plasma, and lymphocyte GSH and a 260% increase in buccal mucosal cells

No se dispone de dosis en miligramos, esquemas de administracin ni pautas validadas para el fragmento aislado en sujetos humanos

This has positioned it as a compound of interest in models investigating combinatorial peptide therapies targeting multiple pathways involved in energy homeostasis