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Injection site reactions are more common with Bydureon due to the long-acting formulation
Importantly, these medications carry a boxed warning about the risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
The gradual dose escalation used in trials is clinically important it is designed to reduce the incidence and severity of nausea, vomiting, and other gastrointestinal adverse effects that are common with this class of medication
It helps preserve muscle during weight loss, supports metabolism, and improves body composition so the weight you lose is more likely to be fat
That is more than double the risk for aggressive weight loss
Those consuming high fat, high volume meals while on tirzepatide typically experience more severe gastrointestinal symptoms than those adjusting to smaller, more frequent, lower fat meals
