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As the authors point out, these findings may help to explain why these metabolic abnormalities occur in a cluster (such as found in the metabolic syndrome), partly because people are exposed to low doses of various POPs simultaneously

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However, the functional relevance of PPAR signaling alone does not fully account for the loss of efficacy observed at doses below 3 mg/kg or above 30 mg/kg (Valeri and Mazzon, 2021)

The retina uses a lot of energy and subsequently produces reactive oxygen species as part of that process

Although promising, these results warrant further research