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L-Cells Release GLP-1 Into the Portal Circulation Activated L-cells secrete GLP-1 directly into the gut and portal vein

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1 In June 2025, the MHRA reinforced this in a public safety update, advising that GLP-1 medicines (a class of weight management and diabetes medications that includes Wegovy, Mounjaro, and Ozempic) must not be taken during pregnancy, while trying to get pregnant, or during breastfeeding

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In 2009, liraglutidea modified human GLP-1 analogue featuring an extended duration of action via fatty acid conjugation and exhibiting approximately 97% sequence identity with native GLP-1was first authorized for therapeutic use in Europe

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