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Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other

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Read more: Essential Tips for Reducing Gas After Gastric Sleeve Surgery Managing Side Effects and When to Seek Help Although GLP-1 receptor agonists are praised for their effectiveness in promoting weight loss and managing Type 2 diabetes, they come with significant challenges

The actual systemic exposure to the infant approaches zero through two independent mechanisms

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Measure week 6 against the week-0 baseline