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For B12, prolonged use of metformin and acid-suppressing drugs (PPIs, H2 blockers) may reduce absorption of oral B12, which is one reason injectable B12 is considered in select patients

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The underlying mechanism involves the Wnt/beta-catenin signaling pathway, which plays a key role in the regulation of the hair cycle

Mild side effects, such as slight soreness at the injection site, may occur but typically resolve quickly

29,30 However, they are important for understanding the current landscape of cannabinoid legality and regulation in the U.S