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A major mechanism for the impact of oxidative stress on vascular tone is the decrease of nitric oxide (NO) bioavailability and/or signaling, leading to endothelial dysfunction, and ROS may also promote vascular cell proliferation and migration, inflammation and apoptosis, as well as extracellular matrix alterations

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For most healthy adults, glutathione supplementation within recommended ranges is considered safe when used appropriately

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The HT treatment remarkably decreased the level of GSH content and GSH/GSSG ratio in cucumber leaves compared to the NT treatment (Fig