Paclitaxel can disrupt mitochondrial function, resulting in the overproduction of ROS such as superoxide anions and hydroxyl radicals, as well as reactive nitrogen species (Sharifi-Rad et al., 2021)
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It will be fascinating to explore the in vivo crosstalk of those key redox couples further in the future, and to understand situations in which the glutathione and NADP redox couples are clearly not coupled, including those documented in this manuscript
Studies on animals show that supplementing glutathione may improve colon damage in those with inflammatory bowel disease
The list of mammalian GPxs has since grown up to eight, numbered one-through-eight
1995 Jun;27(3):237-53