Even trace quantities of certain leachable compounds can be clinically relevant
Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities
Immune support has some research backing it up
Notably, britanin (Bri), a sesquiterpene lactone extracted from Inula japonica, also reduces AMPK phosphorylation, downregulates SREBP1c expression, and alleviates hepatic oxidative stress and apoptosis by decreasing Caspase3 expression and the Bax/Bcl2 ratio, thereby mitigating NAFLD (Dou et al., 2024)
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Many thanks to Professors Peter Jones and Steve ORahilly and Dr Husseini Manji for valuable input and discussions and Dr Vivian Lee for help with gene ontology analysis