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12 (cyanocobalamin) in reducing homocysteine levels and thus cardiovascular risk, recently it has been suggested that an excess of vitamin B 12 might have harmful cerebrovascular consequences (Worthley et al., 2010)

Starting doses are conservative and titrated upward every 4 weeks based on tolerance and response

Common complaints include fatigue, brain fog, shortness of breath, muscle aches, and difficulty concentrating

PMID 15322260

While there is no definitive accounting for how many patients are taking compounded GLP-1 meds, Alliance for Pharmacy Compounding CEO Scott Brunner tells WIRED that he estimates that the number is in the millions

It does not directly interact with tirzepatide or semaglutide at the molecular level, meaning there is no known chemical reaction between creatine and GLP-1 receptor agonists