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Journal of Physiology, 589(Pt 4), 963973

It has been modified to increase potency and extend its half-life to 20-30 hours compared to natural IGF-1

Galani A, et al

PATIENTS with type 2 diabetes treated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may face an increased risk of developing certain autoimmune diseases compared with those on dipeptidyl peptidase-4 inhibitors (DPP-4is), according to new real-world evidence from a large U.S

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Mechanism of action: Activates both GLP-1 receptors AND GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously GIP receptors in fat tissue directly regulate lipid metabolism and fat cell energy storage Dual activation creates a synergistic effect on appetite suppression and energy expenditure Produces stronger improvement in insulin sensitivity compared to GLP-1-only medications FDA-approved brand names: Zepbound approved for chronic weight management Mounjaro approved for type 2 diabetes Why does the dual mechanism matter