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Unlike other forms of regulated cell death, ferroptosis does not rely on a single dedicated executioner protein but instead reflects the balance between pro-oxidant metabolic processes and multilayered defense systems that limit oxidative membrane damage
By enhancing mitochondrial function, NAD+ helps strengthen the heart muscle and supports the efficient delivery of oxygen and nutrients throughout the body
Metabolic transformations and known roles of thiamine and its different natural derivatives are summarized in Table 2
Vitamin B12 also may be involved in maintaining sulfhydryl (SH) groups in the reduced form required by many SH-activated enzyme systems
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It has also been reported that catalase is an important enzyme implicated in mutagenesis and inflammation conditions as well as during the suppression of apoptosis [1518] which are all known to be associated with oxidative stress conditions
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