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Johnson, J
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Behavioral/Non-pharmacologic Treatments Guideline Statement 9 Patients should be educated about normal bladder function, what is known and not known about IC/BPS, the benefits versus risks/burdens of the available treatment alternatives, the fact that no single treatment has been found effective for the majority of patients, and the fact that acceptable symptom control may require trials of multiple therapeutic options (including combination therapy) before it is achieved
However, robust clinical evidence in humans remains limited, with most published data coming from laboratory and animal studies rather than large randomized trials
doi: 10.1038/nm727
Hypoxia preconditioning attenuates bladder overdistension-induced oxidative injury by up-regulation of Bcl-2 in the rat
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