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When activated, GLP-1R slows gastric emptying, reduces glucagon secretion, reduces appetite through central mechanisms, and reduces cardiovascular risk through pathways that are still being elucidated

This triple action appears to make it more potent than existing treatments, though we're yet to see head-to-head comparison studies

By comparison, the dropout rate for the highest dose group in a separate trial for Zepbound was just 6.2%

Only a small minority, fewer than 10%, say usage of GLP-1s is viewed positively

Theory 2: GLP-1 is a miraculous moderation molecule, and it has docking portals all throughout the body that reduce inflammation

Clinical trials show it increases stool frequency and improves stool consistency