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As will be further discussed in section Aging and age retaled diseases, IGF-I and GH levels also decrease with aging (somatopause)[169], reason why a potential strategy for reversing these senile changes in thymic vitality may involve administration of either GH or IGF-I, which have been examined for their potential to expand T-cell populations in animals[170]

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Antioxidant uric acid in treated and untreated subjects with major depressive disorder: a meta-analysis and meta-regression