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Apoptosis inducing factor and mitochondrial NADH dehydrogenases: redox-controlled gear boxes to switch between mitochondrial biogenesis and cell death

Maggirwar SB, Khalsa JH

This is a rare condition caused by an abnormal gene

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Access this article Similar content being viewed by others Abbreviations -GCL: -glutamate cysteine ligase GGT: -glutamyl transferase BSO: L-buthionine-(S, R)-sulfoximine GPx: glutathione peroxidase GSH and GSSG: reduced and oxidized glutathione, respectively MAPK: mitogen-activated protein kinase miR: microRNA Nrf2: NF-E2-related factor 2 ROS: reactive oxygen species REFERENCES Scir, A., Cianfruglia, L., Minnelli, C., Bartolini, D., Torquato, P., Principato, G., Galli, F., and Armeni, T

Enzymatic antioxidant defense cannot rely solely on SOD, because that would result in markedly increased tissue damage due to high accumulated levels of intracellular H 2 O 2 , the substrate for production of OH via the Fenton reaction