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Depending on their localization, this process can occur on the plasma membrane or within intracellular organelles, contributing to ROS presence both in specific cellular compartments and throughout the cytoplasm 49

GRX-PRX partnerships are indicated for proteins shown to functionally interact in peroxidase activity, but these proteins may also interact with other partners

In vitro, cLip-1 prevented the oxidation of membrane lipids and protected cells against the effects of genetic depletion of Gpx4 or pharmacological inhibition of GPX4 with RSL3, thereby recapitulating the biological activity of Lip-1 (Extended Data Fig

10.3390/cells13090764 176 YaoL.ZhaoR.HeS.FengQ.QiaoY.WangP.et al (2022)

RSL3: n = 2 independent experiments

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