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The MCSCF method revealed that the mixing of orbitalsthose occupied by electrons and those unoccupied [92]leads to a significant transfer of electron densities [93,94,95], and even electrons [96, 97], from biological substrates to vitamin B12 cofactors, as well as to the intermolecular orbitals formed between the cofactors and active substrates [93,94,95], aligning theoretical results with experimental observations [2, 90]

Active Gastrointestinal Fluid Losses For a subset of patients, especially during initiation or dose-escalation phases, gastrointestinal side effects can be pronounced: Nausea: Constant, low-grade nausea frequently creates a psychological aversion to swallowing anything, including plain water

These medications are expected to become more widely available this year, and demand for prescriptions is projected to climb substantially

doi: 10.1021/acs.jmedchem.5b00726 96 DeaconCFKnudsenLBMadsenKWibergFCJacobsenOHolstJJ

Recent research supports what clinicians are seeing

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