In these cells, lithium, valproate, carbamazepine and lamotrigine increased the levels of the major antioxidant glutathione and the expression of glutamate-cysteine ligase, the rate-limiting enzyme in glutathione synthesis [97]
= 0.3225)
Contraindications Hypersensitivity to Glutathione
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure
The enzymatic components of the anti-oxidative defense system consist of a number of anti-oxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (GPX) and the enzymes of ascorbate-glutathione (AsA-GSH) cycle namely, ascorbate peroxidase (APX), monodehydroascorbate reductase (MDHAR), dehydroascorbate reductase (DHAR), and glutathione reductase (GR) (Mittler et al., 2004
Therefore, comprehensive consideration of the overall outcomes should be given when developing therapeutic models that regulate global redox states
