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The balance between ACE and ACE2 activity influences the ultimate effect of RAAS, since ANG II promotes vasoconstriction and proliferation while ANG (1,7) stimulates vasodilation and apoptosis ( Recently, three new axes have been identified, emphasizing the role of the kidney in this picture ( The ACE2/ANG(1-7)/Mas receptor pathway ( The prorenin/PRR/MAP kinases ERK1/2 axis: in the past years, renin was considered simply as an enzyme catalyzing the conversion of AGT into ANG I

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