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Food Funct 2, 111116, doi: 10.1039/c0fo00155d (2011)

This clogging leads to inflammation & the development of pimples

Yu IS, Pereira AAL, Lee M, Korphaisarn K, Marshall J, Segelov E, O'Callaghan C, Lim HJ, Kopetz S , Loree JM

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The pathophysiology of endothelial dysfunction is complex, in that it is based on endothelial nitric oxide synthase uncoupling and endothelial activation following stimulation by various inflammatory mediators (molecular patterns, oxidized lipoproteins, and cytokines) (46)