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Quality variance is extreme

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Weight loss typically becomes measurable after two to three weeks of consistent therapy

We therefore investigated whether semaglutide (GLP-1ra), empagliflozin (SGLT2i) or their combination improve kidney oxygenation and perfusion

41 A multicenter phase II study (LEAN) demonstrated the efficacy of liraglutide (a GLP-1 agonist) in NASH resolution based on the disappearance of hepatocyte ballooning without fibrosis worsening among NASH patients after 48 weeks of treatment

KEY POINTS TO REMEMBER Treatment of lipid disorders should be initiated in childhood, since delaying therapy to adulthood may lead to development of cardiovascular diseases as early at a young age