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We therefore hypothesize that the consensus ReED is a negative regulator of NS5B activity with the mutations observed in high replicators unleashing a constitutively active NS5B

Methods Animals All experiments and procedures were performed in accordance with relevant guidelines and regulations and were approved by the local Animal Research Council, University of Leipzig and the Landesbehrde Sachsen (TVV 30/18)

Preclinical animal studies, in vitro mechanistic investigations, and human clinical studies were eligible

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This author had a history of HT-associated subclinical hypothyroidism, which she monitored with periodical checks of serum thyroid function tests and thyroid autoantibodies

This means you need to push through the initial side effect window to reach the benefit window