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These observations can then be interrogated in advanced human-relevant platforms, including patient-derived iPSC-based cardiac organoids and microfluidic organ-on-a-chip systems, to dissect ferroptosis-associated signaling networks in a controlled environment

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mtDNA A3243G MELAS mutation is not associated with multigenerational female migraine

In mouse models, excess levels of SAM have been implicated in erroneous methylation patterns associated with diabetic neuropathy

The discussion explores clinical evidence, common points of failure, lifestyle medicine integration, and how to set realistic patient expectations