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Large randomized controlled trials in humans are absent, so clinical efficacy claims lack robust evidence

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FOXO4-DRI treatment significantly reduced the percentage of tubular cells lacking LMNB1, decreased IL-6 expression, and improved overall renal architecture

This drug is being tested in clinical trials conducted with depressed and chronic pain patients but not AD [29]

This is a black box warning for the entire GLP-1 class based on thyroid C-cell tumor findings in rodent studies

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