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Insulin-like growth factor 1 (IGF-1): a growth hormone
Furthermore, the putative molecules effective in disrupting the FMRP-CYFIP1-eIF4E or eIF4E-eIF4G complexes formation, are required to target protein-protein interaction (PPI) interfaces, that are large, flat and hydrophobic binding surfaces considered as undruggable by small compounds (118120)
Nevertheless, the effect of ethanol consumption on the total hepatic GSH pool is equivocal in that studies have shown decreased, unchanged or increased levels 12,13,14 , most likely related to differences in ethanol exposure regimes and/or analytical assays