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In a STEP-1 extension analysis, participants regained a substantial portion of lost weight after stopping semaglutide (net loss was smaller by week 120)

It's a hormone your own body makes

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has acted as a consultant, advisory board member and speaker for Boehringer Ingelheim, Eli Lilly, Novo Nordisk and Sanofi

Source: Wikipedia Unfortunately, naturally produced GLP-1 in your body is rapidly deactivated by a circulating enzyme called dipeptidyl peptidase IV (or DPP-4 click here to read a previous SoPD post on this enzyme)