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Compared to HC, ME/CFS patients had elevated levels of lactate in both pgACC and dACC, while long COVID patients had lowered levels of total choline in dACC

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Yet, very few clinical trials have looked at the effect of vitamin B 12 , solely, on cognitive endpoints

DAO, or diamine oxidase, is a vital enzyme found in the gut that plays a key regulatory role in maintaining histamine balance

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This can lead to an increase in homocysteine levels, which can inhibit the activity of methionine synthase (MS), the enzyme that converts homocysteine to methionine in the methylation cycle