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The effect of 2.4 mg once-weekly injected semaglutide in patients with HFpEF, obesity and T2D is currently investigated in an ongoing trial STEP-HFpEF DM (Semaglutide Treatment Effect in People with obesity and HFpEF and type 2 diabetes) ( In eight CVOTs history of heart failure was reported at baseline and it ranged from 9% to 24% with no significant difference between patients receivng GLP-1 receptor agonist and patients receiving placebo

Retatrutide is an investigational injectable medicine being developed primarily for the treatment of obesity and type 2 diabetes

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American journal of physiology Regulatory, integrative and comparative physiology