The DAPA-CKD trial, for instance, demonstrated that dapagliflozin significantly reduced the risk of a composite outcome of sustained eGFR decline, end-stage kidney disease, or renal/cardiovascular death by 39% in patients with chronic kidney disease, with consistent benefits observed in participants with and without type 2 diabetes (Savedchuk et al., 2023)
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Can conclusions drawn from animal studies sufficiently support translation to human pathophysiology
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