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As the aesthetic market continues expanding, early adoption of clinically supported antioxidant therapies may offer long-term advantages

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For example, paclitaxel can alter the integrity of the bloodbrain barrier, potentially allowing harmful substances to enter the brain and contributing to neurotoxicity (Patai et al., 2025)

Clinical trials in animal models regularly use higher relative concentrations compared to human anecdotal reports

Age represents one clear response modifier, with some evidence suggesting greater absolute improvements in older patients with more pronounced baseline deficits in matrix density and collagen content

Panyam J, Williams D, Dash A, Leslie-Pelecky D, Labhasetwar V