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In the CNS, MEL is degraded to N-acetyl- N2-formyl-5-methoxycinnamate (AFMK), which is deformed to N-acetyl-5-methoxycinnamate (AMK) (34, 39)

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Imaging and single-cell transcriptomic analyses demonstrate that SGLT2 inhibitors and GLP-1 receptor agonists improve kidney tissue oxygenation and perfusion, respectively [124], and act on distinct kidney cell types [125,126], reinforcing a biological basis for additive or synergistic effects

Therefore, carnitine participation in redox signaling and affecting transcription factors (Nrf2, PPAR, NF-B, etc.) as well as activating the vitagene network are main mechanisms responsible for the antioxidant action of LC and its derivatives

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